PMID:8374073
| Citation |
Borodovsky, M and McIninch, J (1993) Recognition of genes in DNA sequence with ambiguities. BioSystems 30:161-71 |
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| Abstract |
The search for genes in a newly sequenced DNA is a well known problem. Among other factors, the gene-searching process is hampered by a number of ambiguities which may remain unresolved experimentally for a long time. A computer method that is able to predict genes in a DNA sequence containing ambiguities has been developed, based on the non-homogeneous Markov chain technique. The reliability of the method has been tested using a set of sequences generated by a Monte-Carlo procedure and a set of 425 E. coli sequences with ambiguities introduced artificially. |
| Links | |
| Keywords |
DNA/genetics; DNA, Bacterial/genetics; Databases, Factual; Escherichia coli/genetics; Evaluation Studies as Topic; Genes; Genes, Bacterial; Markov Chains; Mathematics; Models, Genetic; Sequence Analysis, DNA/methods; Sequence Analysis, DNA/statistics & numerical data |
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