PMID:8335992

Citation	Cohen, SP, Yan, W and Levy, SB (1993) A multidrug resistance regulatory chromosomal locus is widespread among enteric bacteria. J. Infect. Dis. 168:484-8
Abstract	Constitutive expression of the mar operon (marRAB) in Escherichia coli produces a multiple antibiotic resistance phenotype mediated by the expression of multiple genetic loci in response to regulatory proteins in the operon. A mar-specific DNA probe was used to search for the operon in bacterial strains representing 53 species and 27 genera. Among these, 6 other Enterobacteriaceae, Salmonella, Shigella, Klebsiella, Citrobacter, Hafnia, and Enterobacter species, contained DNA sequences that hybridized to the probe under high-stringency conditions. By use of a selection protocol developed to obtain multiple antibiotic resistant mutants of E. coli, multiply resistant mutants that showed increased expression of mar-specific RNA were obtained from Enterobacter agglomerans and Salmonella species.
Links	PubMed
Keywords	Blotting, Northern; Blotting, Southern; Chromosomes, Bacterial; DNA, Bacterial/analysis; DNA, Bacterial/genetics; Drug Resistance, Microbial/genetics; Enterobacteriaceae/drug effects; Enterobacteriaceae/genetics; Enterobacteriaceae Infections/microbiology; Mutation; Operon; Regulatory Sequences, Nucleic Acid; Salmonella/drug effects; Salmonella/genetics
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