PMID:8332211
| Citation |
Greenblatt, J, Nodwell, JR and Mason, SW (1993) Transcriptional antitermination. Nature 364:401-6 |
|---|---|
| Abstract |
Antiterminator proteins control gene expression by recognizing control signals near the promoter and preventing transcriptional termination which would otherwise occur at sites that may be a long way downstream. The N protein of bacteriophage lambda recognizes a sequence in the nascent RNA, and modifies RNA polymerase by catalysing the formation of a stable ribonucleoprotein complex on its surface, whereas the lambda Q protein recognizes a sequence in the DNA. These mechanisms of antitermination in lambda provide models for analysing antitermination in viruses such as HIV-1 and in eukaryotic genes. |
| Links |
PubMed Online version:10.1038/364401a0 |
| Keywords |
Bacteriophage lambda/genetics; Base Sequence; Gene Products, tat/physiology; HIV-1/genetics; Molecular Sequence Data; Transcription, Genetic/physiology; Viral Proteins/physiology; Viral Regulatory and Accessory Proteins/physiology; tat Gene Products, Human Immunodeficiency Virus |
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