PMID:8256284
| Citation |
Petsko, GA, Kenyon, GL, Gerlt, JA, Ringe, D and Kozarich, JW (1993) On the origin of enzymatic species. Trends Biochem. Sci. 18:372-6 |
|---|---|
| Abstract |
The diversity of enzyme catalytic function is remarkable, particularly when one considers that ancestral life forms must have started with a much smaller ensemble of proteins. In this article, we discuss the evolution of the mandelate pathway in pseudomonads as an example of how catalytic diversity may have evolved. We suggest that existing enzymes that catalyse the chemistry needed to accomplish a transformation were recruited, followed by the evolution of specific binding. |
| Links | |
| Keywords |
Binding Sites; Biological Evolution; Mandelic Acids/metabolism; Protein Structure, Tertiary; Pseudomonas/enzymology; Racemases and Epimerases/chemistry; Racemases and Epimerases/genetics; Racemases and Epimerases/metabolism |
| edit table |
Significance
You can help EcoliWiki by summarizing why this paper is useful
Useful Materials and Methods
You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.
Annotations
<annotationlinks/>
EcoliWiki Links
Add links to pages that link here (e.g. gene, product, method pages)
References
See Help:References for how to manage references in EcoliWiki.