PMID:8236453

Citation	Musacchio, A, Gibson, T, Rice, P, Thompson, J and Saraste, M (1993) The PH domain: a common piece in the structural patchwork of signalling proteins. Trends Biochem. Sci. 18:343-8
Abstract	The 'pleckstrin homology' domain is an approximately 100-residue protein module that has recently been added to the domain catalogue of signalling proteins. For this review we have made an extensive database search using a profile search method, and found a number of additional proteins that may contain PH domains. The PH domain is present in many kinases, isoforms of phospholipase C, GTPases, GTPase-activating proteins and nucleotide-exchange factors, including such proteins as Vav, Dbl and Bcr, and there are two PH domains in a guanine-nucleotide releasing factor of Ras. Many PH-domain-containing proteins interact with GTP-binding proteins. We have also identified a PH domain in beta-adrenergic receptor kinase exactly in the region that has already been shown to be involved in binding to the beta and gamma subunits of a heterotrimeric G protein. This suggests that PH domains may be involved in interactions with GTP-binding proteins.
Links	PubMed
Keywords	Amino Acid Sequence; Animals; Blood Proteins/chemistry; Blood Proteins/metabolism; GTP-Binding Proteins/metabolism; Humans; Molecular Sequence Data; Phosphoproteins; Sequence Homology, Amino Acid; Signal Transduction
edit table

Significance

You can help EcoliWiki by summarizing why this paper is useful

You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.

Add links to pages that link here (e.g. gene, product, method pages)

See Help:References for how to manage references in EcoliWiki.