PMID:8183345
| Citation |
Maeda, T, Wurgler-Murphy, SM and Saito, H (1994) A two-component system that regulates an osmosensing MAP kinase cascade in yeast. Nature 369:242-5 |
|---|---|
| Abstract |
In the prokaryotic two-component signal transduction systems, recognition of an environmental stimulus by a sensor molecule results in the activation of its histidine kinase domain and phosphorylation of a histidine residue within that domain. This phosphate group is then transferred to an aspartate residue in the receiver domain of a cognate response regulator molecule, resulting in the activation of its output function. Although a few eukaryotic proteins were identified recently that show sequence similarity to the prokaryotic sensors or response regulators, it has not been clear whether they constituted a part of a 'two-component' system. Here we describe a two-component system in Saccharomyces cerevisiae that regulates an osmosensing MAP kinase cascade. |
| Links |
PubMed Online version:10.1038/369242a0 |
| Keywords |
Amino Acid Sequence; Fungal Proteins/genetics; Fungal Proteins/metabolism; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; Mutation; Phosphoprotein Phosphatases/metabolism; Phosphorylation; Protein Kinases/genetics; Protein Kinases/metabolism; Protein Phosphatase 2; Protein Tyrosine Phosphatases/genetics; Protein Tyrosine Phosphatases/metabolism; Saccharomyces cerevisiae/enzymology; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/metabolism; Saccharomyces cerevisiae Proteins; Signal Transduction; Suppression, Genetic |
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