PMID:8169229

Citation	Mukherjee, A and Lutkenhaus, J (1994) Guanine nucleotide-dependent assembly of FtsZ into filaments. J. Bacteriol. 176:2754-8
Abstract	FtsZ is an essential cell division protein that is localized to the leading edge of the bacterial septum in a cytokinetic ring. It contains the tubulin signature motif and is a GTP binding protein with a GTPase activity. Further comparison of FtsZ with eukaryotic tubulins revealed some additional sequence similarities, perhaps indicating a similar GTP binding site. Examination of FtsZ incubated in vitro by electron microscopy revealed a guanine nucleotide-dependent assembly into protein filaments, supporting the hypothesis that the FtsZ ring is formed through self-assembly. FtsZ3, which is unable to bind GTP, does not polymerize, whereas FtsZ2, which binds GTP but is deficient in GTP hydrolysis, is capable of polymerization.
Links	PubMed PMC205420
Keywords	Amino Acid Sequence; Bacterial Proteins/drug effects; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Bacterial Proteins/ultrastructure; Cytoskeletal Proteins; Escherichia coli; GTP-Binding Proteins/drug effects; GTP-Binding Proteins/genetics; GTP-Binding Proteins/metabolism; GTP-Binding Proteins/ultrastructure; Guanine Nucleotides/pharmacology; Molecular Sequence Data; Negative Staining; Sequence Homology, Amino Acid; Tubulin/genetics
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