PMID:8152423

Citation	Levinthal, M, Lejeune, P and Danchin, A (1994) The H-NS protein modulates the activation of the ilvIH operon of Escherichia coli K12 by Lrp, the leucine regulatory protein. Mol. Gen. Genet. 242:736-43
Abstract	The H-NS protein, the product of the hns gene, plays a central role in the cellular response of bacteria to environmental stresses such as modification of osmolarity and temperature. The leucine regulatory protein (Lrp) controls a wide array of operons both as an activator (e.g. ilvIH) and as a repressor. We demonstrate that H-NS can decrease the activity of Lrp in stationary phase and under conditions of high osmolarity. Strains containing hns mutations have higher levels of Lrp-activated ilvIH transcription, while strains carrying the hns+ allele on a pBR322 plasmid have lower activity of Lrp-directed ilvIH gene expression.
Links	PubMed
Keywords	Alleles; Bacterial Outer Membrane Proteins/genetics; Bacterial Proteins/genetics; DNA-Binding Proteins/genetics; Escherichia coli/genetics; Escherichia coli/growth & development; Escherichia coli/metabolism; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Genes, Bacterial; Leucine-Responsive Regulatory Protein; Multigene Family; Mutation; Operon; Regulon; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Water-Electrolyte Balance/genetics
edit table

Significance

You can help EcoliWiki by summarizing why this paper is useful

You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.

Add links to pages that link here (e.g. gene, product, method pages)

See Help:References for how to manage references in EcoliWiki.