PMID:8146657

Citation	Harris, RS, Longerich, S and Rosenberg, SM (1994) Recombination in adaptive mutation. Science 264:258-60
Abstract	The genetic requirements for adaptive mutation in Escherichia coli parallel those for homologous recombination in the RecBCD pathway. Recombination-deficient recA and recB null mutant strains are deficient in adaptive reversion. A hyper-recombinagenic recD strain is hypermutable, and its hypermutation depends on functional recA and recB genes. Genes of subsidiary recombination systems are not required. These results indicate that the molecular mechanism by which adaptive mutation occurs includes recombination. No such association is seen for spontaneous mutation in growing cells.
Links	PubMed
Keywords	DNA Damage; DNA, Bacterial/genetics; Escherichia coli/genetics; Escherichia coli Proteins; Exodeoxyribonuclease V; Exodeoxyribonucleases/genetics; Frameshift Mutation; Genes, Bacterial; Lac Operon; Models, Genetic; Mutagenesis; Rec A Recombinases/genetics; Recombination, Genetic; Templates, Genetic
edit table

Significance

You can help EcoliWiki by summarizing why this paper is useful

You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.

Add links to pages that link here (e.g. gene, product, method pages)

See Help:References for how to manage references in EcoliWiki.