PMID:8022262
| Citation |
Saier, MH Jr, Tam, R, Reizer, A and Reizer, J (1994) Two novel families of bacterial membrane proteins concerned with nodulation, cell division and transport. Mol. Microbiol. 11:841-7 |
|---|---|
| Abstract |
Homology has been established for members of two families of functionally related bacterial membrane proteins. The first family (the resistance/nodulation/cell division (RND) family) includes (i) two metal-resistance efflux pumps in Alcaligenes eutrophus (CzcA and CnrA), (ii) three proteins which function together in nodulation of alfalfa roots by Rhizobium meliloti (NoIGHI), and (iii) a cell division protein in Escherichia coli (EnvD). The second family (the putative membrane fusion protein (MFP) family) includes a nodulation protein (NoIF), a cell division protein (EnvC), and a multidrug resistance transport protein (EmrA). We propose that an MFP functions co-operatively with an RND protein to transport large or hydrophobic molecules across the two membranes of the Gram-negative bacterial cell envelope. |
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| Keywords |
Alcaligenes/chemistry; Alcaligenes/genetics; Alcaligenes/physiology; Amino Acid Sequence; Bacterial Outer Membrane Proteins/classification; Bacterial Outer Membrane Proteins/genetics; Bacterial Outer Membrane Proteins/metabolism; Bacterial Proteins/classification; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Biological Transport/genetics; Carrier Proteins/classification; Carrier Proteins/genetics; Carrier Proteins/metabolism; Cell Division/genetics; Consensus Sequence; Drug Resistance, Microbial/genetics; Escherichia coli/chemistry; Escherichia coli/genetics; Escherichia coli/physiology; Escherichia coli Proteins; Genes, Bacterial; Medicago sativa/microbiology; Membrane Proteins/classification; Membrane Proteins/genetics; Membrane Proteins/metabolism; Metals/pharmacology; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Multigene Family; Operon; Sequence Alignment; Sequence Homology, Amino Acid; Sinorhizobium meliloti/chemistry; Sinorhizobium meliloti/genetics; Sinorhizobium meliloti/physiology |
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