PMID:8002599
| Citation |
Fowler, RG, Erickson, JA and Isbell, RJ (1994) Activity of the Escherichia coli mutT mutator allele in an anaerobic environment. J. Bacteriol. 176:7727-9 |
|---|---|
| Abstract |
Mutation frequencies for an Escherichia coli mutT strain were measured in both aerobic and anaerobic environments. When cells were grown in a rich medium (L broth), mutation frequencies were similar in both aerobic and anaerobic conditions. In contrast, when grown in a minimal medium, mutT anaerobic mutation frequencies were reduced dramatically compared with aerobic values, which were similar to L broth frequencies. L broth mutT cultures treated with a commercial enzyme complex that reduces free oxygen in the medium also showed strongly reduced anaerobic mutation frequencies. These results indicate that the biological role of the MutT protein is to prevent oxidative damage from becoming mutagenic. |
| Links | |
| Keywords |
Aerobiosis; Alleles; Anaerobiosis; DNA Damage; DNA Repair; Escherichia coli/genetics; Genes, Bacterial/genetics; Mutagenesis/genetics |
| edit table |
Significance
You can help EcoliWiki by summarizing why this paper is useful
Useful Materials and Methods
You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.
Annotations
<annotationlinks/>
EcoliWiki Links
Add links to pages that link here (e.g. gene, product, method pages)
References
See Help:References for how to manage references in EcoliWiki.