PMID:7937065
| Citation |
Attwood, TK, Beck, ME, Bleasby, AJ and Parry-Smith, DJ (1994) PRINTS--a database of protein motif fingerprints. Nucleic Acids Res. 22:3590-6 |
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| Abstract |
PRINTS is a compendium of protein motif 'fingerprints'. A fingerprint is defined as a group of motifs excised from conserved regions of a sequence alignment, whose diagnostic power or potency is refined by iterative databasescanning (in this case the OWL composite sequence database). Generally, the motifs do not overlap, but are separated along a sequence, though they may be contiguous in 3D-space. The use of groups of independent, linearly- or spatially-distinct motifs allows protein folds and functionalities to be characterised more flexibly and powerfully than conventional single-component patterns or regular expressions. The current version of the database contains 200 entries (encoding 950 motifs), covering a wide range of globular and membrane proteins, modular polypeptides, and so on. The growth of the databaseis influenced by a number of factors; e.g. the use of multiple motifs; the maximisation of sequence information through iterative database scanning; and the fact that the database searched is a large composite. The information contained within PRINTS is distinct from, but complementary to the consensus expressions stored in the widely-used PROSITE dictionary of patterns. |
| Links | |
| Keywords |
Amino Acid Sequence; Amino Acids; Computer Communication Networks; Conserved Sequence; Databases, Factual; Molecular Sequence Data; Peptide Mapping; Proteins/chemistry; Software |
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