PMID:7934880

Citation	Ivanova, A, Miller, C, Glinsky, G and Eisenstark, A (1994) Role of rpoS (katF) in oxyR-independent regulation of hydroperoxidase I in Escherichia coli. Mol. Microbiol. 12:571-8
Abstract	We present evidence showing that rpoS (katF) is a regulator of katG gene transcription in an oxyR-independent manner. Mutation of the rpoS gene in several different Escherichia coli strains caused a significant reduction in catalase HPI activity. In rpoS-delta oxyR double mutants, the level of HPI was considerably lower compared to the delta oxyR parent strain, and was restored when transformed with an rpoS+ plasmid. Overproduction of HPI in oxyR- suppressor strains was greatly diminished after inactivation of the rpoS gene and was accompanied by a substantial increase in sensitivity to menadione. Beta-galactosidase expression from a katG::lacZ promoter was lower in rpoS strains compared to rpoS+ isogenic parents. Several delta oxyR strains had detectable levels of katG transcription that was significantly diminished after rpoS gene inactivation.
Links	PubMed
Keywords	Catalase/genetics; Drug Resistance, Microbial/genetics; Escherichia coli/drug effects; Escherichia coli/enzymology; Escherichia coli/genetics; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Genes, Bacterial; Genes, Regulator; Genes, Suppressor; Lac Operon; Mutation; Transcription, Genetic; Vitamin K/pharmacology
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