PMID:7926678
| Citation |
Ayala, J, Goffin, C, Nguyen-Distèche, M and Ghuysen, JM (1994) Site-directed mutagenesis of penicillin-binding protein 3 of Escherichia coli: role of Val-545. FEMS Microbiol. Lett. 121:251-6 |
|---|---|
| Abstract |
Val545 of the Escherichia coli penicillin-binding protein 3 is essential to the acyl transfer mechanism through which the active-site serine 307 is acylated by benzylpenicillin and cephalexin and to the mechanism through which the protein allows rapidly growing cells to divide. |
| Links | |
| Keywords |
Bacterial Proteins; Base Sequence; Carrier Proteins/genetics; DNA, Complementary; Escherichia coli/chemistry; Escherichia coli/genetics; Escherichia coli/growth & development; Escherichia coli Proteins; Hexosyltransferases; Molecular Sequence Data; Muramoylpentapeptide Carboxypeptidase/genetics; Mutagenesis, Site-Directed; Penicillin-Binding Proteins; Peptidoglycan Glycosyltransferase; Peptidyl Transferases; Valine/genetics |
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