PMID:7899506
| Citation |
Kim, ST and Sancar, A (1995) Photorepair of nonadjacent pyrimidine dimers by DNA photolyase. Photochem. Photobiol. 61:171-4 |
|---|---|
| Abstract |
Photolyases reverse the harmful effects of UV light on cells by converting pyrimidine dimers (Pyr[]Pyr) into two pyrimidine monomers by utilizing near-UV and visible light. Previous work has shown that photolyase repairs T[c,s]T and T[t,s]T in DNA as well as U[]U in RNA, all of which are formed by joining the two adjacent pyrimidines in a light-dependent reaction. In this report, we show that Pyr[]Pyr formed in nonadjacent pyrimidines are also substrates for DNA photolyase. |
| Links | |
| Keywords |
DNA Repair; Deoxyribodipyrimidine Photo-Lyase/metabolism; Escherichia coli/enzymology; Pyrimidine Dimers/metabolism; Substrate Specificity; Ultraviolet Rays |
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