PMID:7748933
| Citation |
Oberto, J, Drlica, K and Rouvière-Yaniv, J (1994) Histones, HMG, HU, IHF: Même combat. Biochimie 76:901-8 |
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| Abstract |
In this review article we present a compilation of the proteins homologous to Escherichia coli HU: the HU-like family. Two of these, HU and IHF from E coli have been extensively characterized genetically and biochemically. Due to their DNA binding activities, these proteins confer a condensed shape to the chromosome and regulate the transcription of selected sets of its genes. The parallel between the dual function of the HU-like proteins and the roles described for eukaryotic histone and HMG proteins is striking, especially in the view that they are evolutionary unrelated. |
| Links | |
| Keywords |
Amino Acid Sequence; Bacterial Proteins/chemistry; DNA-Binding Proteins/chemistry; High Mobility Group Proteins/chemistry; Histones/chemistry; Integration Host Factors; Molecular Sequence Data; Sequence Homology, Amino Acid; Transcription Factors/chemistry |
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