PMID:7748928

Citation	Landgraf, JR, Levinthal, M and Danchin, A (1994) The role of H-NS in one carbon metabolism. Biochimie 76:1063-70
Abstract	The H-NS protein of Escherichia coli regulates the expression of genes involved in many general processes such as osmoregulation and virulence. More recently, H-NS was shown to exert an effect on ilvIH gene expression in conjunction with the leucine responsive regulatory protein (Lrp). We show that H-NS is involved in the transcriptional regulation of the kbl/tdh operon, which is also Lrp regulated. Insertional inactivation of the hns gene results in two-fold derepression of the kbl/tdh operon. This level of expression is sufficient to suppress the auxotrophic requirements imposed by a glyA mutation. We show that expression of the kbl/tdh operon is temperature controlled and that this control is not mediated through H-NS action as has been shown for some other temperature controlled genes.
Links	PubMed
Keywords	Alcohol Oxidoreductases/genetics; Amino Acid Sequence; Bacterial Outer Membrane Proteins/physiology; Bacterial Proteins; Base Sequence; Carbon/metabolism; Cloning, Molecular; Cyclic AMP/physiology; DNA-Binding Proteins/physiology; Gene Deletion; Gene Expression Regulation, Bacterial/physiology; Genes, Reporter; Molecular Sequence Data; Mutation; Operon; Suppression, Genetic; beta-Galactosidase/genetics
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