PMID:7665533
| Citation |
King, SC, Fleming, SR and Brechtel, C (1995) Pyridine carboxylic acids as inhibitors and substrates of the Escherichia coli gab permease encoded by gabP. J. Bacteriol. 177:5381-2 |
|---|---|
| Abstract |
Although considered selective for its natural substrate, 4-aminobutyrate, gab permease was inhibited by 1,2,3,6-tetrahydro-3-pyridinecarboxylate and 1,2,3,6-tetrahydro-4-pyridinecarboxylate. The former is a transported substrate, since its preloading into metabolically poisoned cells stimulated transient accumulation of 4-aminobutyrate via counterflow. |
| Links | |
| Keywords |
Biological Transport; Escherichia coli/enzymology; Escherichia coli/genetics; Escherichia coli Proteins; GABA Plasma Membrane Transport Proteins; Genes, Bacterial; Membrane Transport Modulators; Membrane Transport Proteins/antagonists & inhibitors; Membrane Transport Proteins/metabolism; Nicotinic Acids/pharmacology; Nipecotic Acids/metabolism; Organic Anion Transporters; Piperidines/pharmacology; Proline/analogs & derivatives; Substrate Specificity; gamma-Aminobutyric Acid/metabolism |
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