PMID:765765

Citation	Srivastava, BS (1976) Radiation sensitivity of a mutant of Escherichia coli K-12 associated with DNA replication: evidence for a new repair function. Mol. Gen. Genet. 143:327-32
Abstract	The isolation and properties of a new radiation sensitive mutant of Escherichia coli K-12 are described which shows a correlation between radiation sensitivity and replication of irradiated DNA. The mutation, called rer, is located between arg B and pur D loci. The mutant, when grown in tryptone broth after irradiation, is sensitive to UV and lambda-rays and incorporates little or no 3H-thymidine but in minimal glucose-salts medium both the radiation sensitivity and incorporation of 3H-thymidine remain identical to that of the parent strain. Studies with a temperature sensitive double mutant rer dnaC show that 1 hr incubation of irradiated cells at 42 degrees C before their transfer to 30 degrees C results in higher survival as compared to their incubation at 30 degrees C only. It is suggested that rer controls the replication of irradiated DNA and thus regulates the coordination between replication and repair of DNA.
Links	PubMed
Keywords	Coliphages/radiation effects; DNA Repair; DNA Replication; Escherichia coli/isolation & purification; Escherichia coli/radiation effects; Gamma Rays; Genetic Linkage; Mutation; Radiation Genetics; Ultraviolet Rays
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