PMID:7651128

Citation	Goosen, N and van de Putte, P (1995) The regulation of transcription initiation by integration host factor. Mol. Microbiol. 16:1-7
Abstract	Integration host factor (IHF) of Escherichia coli is an asymmetric histone-like protein that binds and bends the DNA at specific sequences. IHF functions as an accessory factor in a wide variety of processes including replication, site-specific recombination and transcription. In many of these processes IHF was shown to act as an architectural element which helps the formation of nucleo-protein complexes by bending of the DNA at specific sites. This MicroReview shows how such a structural role of IHF can influence the initiation of transcription. In addition, it summarizes the evidence indicating that IHF can stimulate transcription via a direct interaction with RNA polymerase and explores the possibility that the asymmetry of the IHF protein might reflect such an interaction.
Links	PubMed
Keywords	Bacterial Proteins/physiology; Base Sequence; Binding Sites; DNA-Binding Proteins/physiology; DNA-Directed RNA Polymerases/metabolism; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Integration Host Factors; Models, Genetic; Molecular Sequence Data; Promoter Regions, Genetic; RNA Polymerase II/metabolism; RNA Polymerase Sigma 54; Sigma Factor/metabolism; Transcription, Genetic
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