PMID:7635836
| Citation |
Bianchi, V, Haggård-Ljungquist, E, Pontis, E and Reichard, P (1995) Interruption of the ferredoxin (flavodoxin) NADP+ oxidoreductase gene of Escherichia coli does not affect anaerobic growth but increases sensitivity to paraquat. J. Bacteriol. 177:4528-31 |
|---|---|
| Abstract |
Ferredoxin (flavodoxin) NADP+ oxidoreductase participates in methionine biosynthesis and in the function of two anaerobic enzymes, pyruvate formate-lyase and ribonucleotide reductase. We prepared insertion mutants of Escherichia coli lacking a functional enzyme. They do not require methionine and they grow well anaerobically, but they show increased sensitivity to paraquat. |
| Links | |
| Keywords |
Acetyltransferases/genetics; Acetyltransferases/metabolism; Anaerobiosis; Base Sequence; DNA Transposable Elements/genetics; Escherichia coli/drug effects; Escherichia coli/enzymology; Escherichia coli/genetics; Ferredoxin-NADP Reductase/biosynthesis; Ferredoxin-NADP Reductase/genetics; Ferredoxin-NADP Reductase/isolation & purification; Gene Expression Regulation, Bacterial/drug effects; Gene Expression Regulation, Enzymologic/drug effects; Molecular Sequence Data; Mutagenesis, Site-Directed; Paraquat/pharmacology; Plasmids/genetics; Ribonucleotide Reductases/genetics; Ribonucleotide Reductases/metabolism |
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