PMID:7590157

Citation	van Heeswijk, WC, Stegeman, B, Hoving, S, Molenaar, D, Kahn, D and Westerhoff, HV (1995) An additional PII in Escherichia coli: a new regulatory protein in the glutamine synthetase cascade. FEMS Microbiol. Lett. 132:153-7
Abstract	The PII protein in the glutamine synthetase cascade transduces the nitrogen signal, as sensed by uridylyltransferase, both to the NRII/NRI two-component system and to adenylyltransferase, to regulate the activity of glutamine synthetase. Here we describe the amplification of a chromosomal DNA fragment from Escherichia coli which contains the sequence of a PII homologue. The derived amino acid sequence of this DNA fragment is 67% identical to E. coli PII. It contains the conserved tyrosine residue which is known to be the site of uridylylation in PII. E. coli is the first organism in which two different PII proteins have been detected.
Links	PubMed
Keywords	Amino Acid Sequence; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Base Sequence; DNA, Bacterial; Enzyme Induction; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins; Gene Amplification; Glutamate-Ammonia Ligase/genetics; Glutamate-Ammonia Ligase/metabolism; Molecular Sequence Data; Nitrogen/metabolism; PII Nitrogen Regulatory Proteins; Protein Kinases/genetics; Protein Kinases/isolation & purification; Protein Kinases/metabolism; Sequence Homology; Signal Transduction; Transcription Factors
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