PMID:7545940
| Citation |
Huisman, GW and Kolter, R (1994) Sensing starvation: a homoserine lactone--dependent signaling pathway in Escherichia coli. Science 265:537-9 |
|---|---|
| Abstract |
When nutrients become limiting, many bacteria differentiate and become resistant to environmental stresses. For Escherichia coli, this process is mediated by the sigma s subunit of RNA polymerase. Expression of sigma s was induced by homoserine lactone, a metabolite synthesized from intermediates in threonine biosynthesis. Homoserine lactone-dependent synthesis of sigma s was prevented by overexpression of a newly identified protein, RspA. The function of homoserine lactone derivatives in many cell density-dependent phenomena and the similarity of RspA to a Streptomyces ambofaciens protein suggest that synthesis of homoserine lactone may be a general signal of starvation. |
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| Keywords |
4-Butyrolactone/analogs & derivatives; 4-Butyrolactone/metabolism; 4-Butyrolactone/pharmacology; Amino Acid Sequence; Bacterial Proteins/biosynthesis; Bacterial Proteins/chemistry; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Catalase/metabolism; Escherichia coli/genetics; Escherichia coli/metabolism; Gene Expression Regulation, Bacterial; Models, Biological; Molecular Sequence Data; Operon; Phenotype; Sigma Factor/biosynthesis; Sigma Factor/genetics; Signal Transduction; Transcription, Genetic; Vibrio/genetics |
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