PMID:7504905
| Citation |
Yura, T, Nagai, H and Mori, H (1993) Regulation of the heat-shock response in bacteria. Annu. Rev. Microbiol. 47:321-50 |
|---|---|
| Abstract |
When bacteria cells are exposed to higher temperature, a set of heat-shock proteins (hsps) is induced rapidly and transiently to cope with increased damage in proteins. The mechanism underlying induction of hsps has been a central issue in the heat-shock response and studied intensively in Escherichia coli. Immediately upon temperature upshift, the cellular level of sigma 32 responsible for transcription of heat-shock genes increases rapidly and transiently. The increase in sigma 32 results from both increased synthesis and stabilization of sigma 32, which is ordinarily very unstable. A clue to further understanding of early regulatory events came from recent analysis of translational induction and subsequent shut-off of sigma 32 synthesis. Whereas a 5'-coding region of mRNA for sigma 32 is involved in the induction mediated by the mRNA secondary structure, a distinct segment of sigma 32 polypeptide further downstream is involved in the DnaK/DnaJ-mediated shut-off and destabilization of sigma 32 that may be mutually interconnected. |
| Links |
PubMed Online version:10.1146/annurev.mi.47.100193.001541 |
| Keywords |
Bacteria/genetics; Bacteria/metabolism; Base Sequence; DNA, Bacterial; Gene Expression Regulation, Bacterial; Heat-Shock Proteins/genetics; Heat-Shock Proteins/metabolism; Molecular Sequence Data; RNA, Bacterial; Sigma Factor/genetics; Sigma Factor/metabolism; Transcription Factors |
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