PMID:7022128
| Citation |
Ursini, MV, Arcari, P and De Felice, M (1981) Acetohydroxy acid synthase isoenzymes of Escherichia coli K-12: a trans-acting regulatory locus of ilvHI gene expression. Mol. Gen. Genet. 181:491-6 |
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| Abstract |
We isolated an Escherichia coli K-12 regulatory mutation affecting the acetohydroxy acid synthase III isoenzyme. This mutation was found to lie outside the structural genes ilvHI for this isoenzyme and was designated lrs-1. A strain carrying this mutation was found to be altered in the leucine-mediated control of ilvHI mRNA and acetohydroxy acid synthase III synthesis observed in the isogenic lrs+ strain. These alterations appeared to be a consequence of a reduced intracellular concentration of a single one of five tRNALeu isoaccepting species. |
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| Keywords |
Acetolactate Synthase/genetics; Escherichia coli/genetics; Gene Expression Regulation; Genes, Dominant; Genes, Regulator; Isoenzymes/genetics; Isoleucine/biosynthesis; Leucine/biosynthesis; Mutation; Oxo-Acid-Lyases/genetics; RNA, Messenger/biosynthesis; RNA, Transfer, Amino Acyl/metabolism; Valine/biosynthesis |
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