PMID:6991475
| Citation |
Staskawicz, BJ and Panopoulos, NJ (1980) Phaseolotoxin transport in Escherichia coli and Salmonella typhimurium via the oligopeptide permease. J. Bacteriol. 142:474-9 |
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| Abstract |
Phaseolotoxin [(N delta-phosphosulfamyl)ornithylalanylhomoarginine], a phytotoxic tripeptide produced by Pseudomonas syringae pv. phaseolicola that inhibits ornithine carbamoyltransferase, is transported into Escherichia coli and Salmonella typhimurium via the oligopeptide transport system (Opp). Mutants defective in oligopeptide permease (Opp-) were resistant to phaseolotoxin. Spontaneous phaseolotoxin-resistant mutants (Toxr) lacked the Opp function as evidenced by their cross-resistance to triornithine and failure to utilize glycylhistidylglycine as a source of histidine. Growth inhibition by phaseolotoxin was prevented by peptides known to be transported via the Opp system and by treatment of the toxin with L-aminopeptidase. In both E. coli and S. typhimurium, Toxr mutations were cotransducible with trp, suggesting that the opp locus occupies similar positions in genetic maps of these bacteria. |
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| Keywords |
Bacterial Toxins/metabolism; Bacterial Toxins/pharmacology; Chromosome Mapping; Drug Resistance, Microbial; Escherichia coli/genetics; Escherichia coli/metabolism; Membrane Transport Proteins/metabolism; Mutation; Oligopeptides; Pseudomonas; Salmonella typhimurium/genetics; Salmonella typhimurium/metabolism |
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