PMID:6760806
| Citation |
Jaffe, A, Chabbert, YA and Semonin, O (1982) Role of porin proteins OmpF and OmpC in the permeation of beta-lactams. Antimicrob. Agents Chemother. 22:942-8 |
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| Abstract |
Mutants of Escherichia coli K-12 lacking major outer membrane proteins were obtained by selecting for resistance to the beta-lactam cefoxitin. Three classes of resistant strains were found: mutants in ompB, a regulatory locus for proteins OmpF and OmpC; mutants in ompF; and one mutant in tpo. The OmpF and OmpC proteins facilitate penetration of beta-lactams through the outer membrane. |
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| Keywords |
Anti-Bacterial Agents/metabolism; Bacterial Outer Membrane Proteins; Bacterial Proteins/metabolism; Carrier Proteins/metabolism; Cell Membrane Permeability; Escherichia coli/drug effects; Escherichia coli/genetics; Escherichia coli/metabolism; Hexosyltransferases; Membrane Proteins/metabolism; Microbial Sensitivity Tests; Muramoylpentapeptide Carboxypeptidase; Penicillin-Binding Proteins; Peptidyl Transferases; beta-Lactams |
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