PMID:6433
| Citation |
Pugsley, AP and Reeves, P (1976) Characterization of group B colicin-resistant mutants of Escherichia coli K-12: colicin resistance and the role of enterochelin. J. Bacteriol. 127:218-28 |
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| Abstract |
Nine classes of group B colicin-resistant mutants were examined to study the role of enterochelin in colicin resistance. Four of the mutants studied (cbt, exbC, exbB, and tonB) hypersecreted enterochelin. Enterochelin hypersecretion was apparently responsible for resistance of the exbC mutant to colicins G and H and for resistance of the exbB mutant to colicins G, H, Ia, Ib, S1, and V. All four mutants scored as colicin B tolerant, even in the absence of enterochelin synthesis. The mutants produced substantially increased amounts of two high-molecular-weight outer membrane polypeptides when grown under limiting iron conditions. The presence of these polypeptides was correlated with increased colicin B-neutralizing activity in the outer membrane preparations. |
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| Keywords |
2,2'-Dipyridyl/pharmacology; Bacterial Proteins/biosynthesis; Cell Membrane/metabolism; Citrates/pharmacology; Colicins/pharmacology; Deferoxamine/pharmacology; Drug Resistance, Microbial; Edetic Acid/pharmacology; Enterobactin/metabolism; Enterobactin/pharmacology; Escherichia coli/drug effects; Escherichia coli/metabolism; Genes; Molecular Weight; Mutation; Peptide Biosynthesis; Serine/analogs & derivatives |
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