PMID:6384194
| Citation |
Sandulache, R, Prehm, P and Kamp, D (1984) Cell wall receptor for bacteriophage Mu G(+). J. Bacteriol. 160:299-303 |
|---|---|
| Abstract |
The invertible G segment in phage Mu DNA controls the host range of the phage. Depending on the orientation of the G segment, two types of phage particles, G(+) and G(-), are produced which recognize different cell surface receptors. The receptor for Mu G(+) was located in the lipopolysaccharide (LPS) of gram-negative bacteria. The analysis of different LPS core types and of mutants that were made resistant to Mu G(+) shows that the primary receptor site on Escherichia coli K-12 lies in the GlcNAc beta 1 . . . 6Glc alpha 1-2Glc alpha 1-part at the outer end of the LPS. Mu shares this receptor site in E. coli K-12 with the unrelated single-stranded DNA phage St-1. Phage D108, which is related to Mu, and phages P1 and P7, which are unrelated to Mu but contain a homologous invertible DNA segment, have different receptor requirements. Since they also bind to terminal glucose in a different configuration, they adsorb to and infect E. coli K-12 strains with an incomplete LPS core. |
| Links | |
| Keywords |
Coliphages/drug effects; Coliphages/metabolism; Escherichia coli/genetics; Escherichia coli/metabolism; Lipopolysaccharides/genetics; Lipopolysaccharides/metabolism; Mutation; Receptors, Virus/metabolism; Species Specificity |
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