PMID:6382166
| Citation |
Van Vliet, F, Cunin, R, Jacobs, A, Piette, J, Gigot, D, Lauwereys, M, Piérard, A and Glansdorff, N (1984) Evolutionary divergence of genes for ornithine and aspartate carbamoyl-transferases--complete sequence and mode of regulation of the Escherichia coli argF gene; comparison of argF with argI and pyrB. Nucleic Acids Res. 12:6277-89 |
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| Abstract |
The complete nucleotide sequence of argF is presented, together with that of an operator-constitutive mutant. ArgF is compared with the other gene coding for ornithine carbamoyltransferase (OTCase) in E. coli K-12, argI, and with pyrB, encoding the catalytic monomer of aspartate carbamoyltransferase (ATCase). ArgF and argI appear very closely related having emerged from a relatively recent ancestor gene. The relationship between OTCase and ATCase appears more distant. Nevertheless, the homology observed between the two proteins (mainly in the polar domain) suggests a common origin. |
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| Keywords |
Arginine/genetics; Aspartate Carbamoyltransferase/genetics; Base Sequence; Biological Evolution; Codon; Escherichia coli/genetics; Gene Expression Regulation; Genes; Genes, Bacterial; Mutation; Operon; Ornithine Carbamoyltransferase/genetics; Protein Conformation |
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