PMID:6344786
| Citation |
Jaffé, A, Chabbert, YA and Derlot, E (1983) Selection and characterization of beta-lactam-resistant Escherichia coli K-12 mutants. Antimicrob. Agents Chemother. 23:622-5 |
|---|---|
| Abstract |
beta-Lactam-resistant mutants of Escherichia coli K-12 were selected by using 12 different beta-lactam derivatives. The mutants fell into three categories showing (i) altered permeation through reduction or loss of outer membrane porin proteins (including ompF, ompR, and envZ alleles); (ii) increase in the rate of synthesis of chromosomally mediated beta-lactamase; or (iii) defective synthesis or action of cyclic adenosine 3',5'-phosphate (cya and crp alleles). |
| Links | |
| Keywords |
Anti-Bacterial Agents/pharmacology; Drug Resistance, Microbial; Escherichia coli/drug effects; Escherichia coli/genetics; Mutation; beta-Lactamases/biosynthesis; beta-Lactams |
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