PMID:6333513
| Citation |
Hamilton, DL and Abremski, K (1984) Site-specific recombination by the bacteriophage P1 lox-Cre system. Cre-mediated synapsis of two lox sites. J. Mol. Biol. 178:481-6 |
|---|---|
| Abstract |
The bacteriophage P1-encoded recombinase Cre forms a simple DNA-protein complex at the specific recognition site loxP. Furthermore, Cre is able to mediate a synaptic union of two loxP sites. When two loxP sites are on the same linear DNA molecule, Cre binds the two sites together to form a circular protein-DNA complex. These complexes can be resolved into a linear DNA molecule and a closed circular DNA molecule, the end products of site-specific recombination. |
| Links | |
| Keywords |
Base Sequence; Coliphages/genetics; Coliphages/metabolism; DNA, Viral/metabolism; Microscopy, Electron; Plasmids; Recombination, Genetic; Viral Proteins/genetics; Viral Proteins/metabolism |
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