PMID:6284712
| Citation |
Utsumi, R, Nakamoto, Y, Kawamukai, M, Himeno, M and Komano, T (1982) Involvement of cyclic AMP and its receptor protein in filamentation of an Escherichia coli fic mutant. J. Bacteriol. 151:807-12 |
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| Abstract |
Cyclic AMP (cAMP) inhibited septum formation in Escherichia coli PA3092 and induced cell filamentation at elevated temperatures. This phenomenon was first observed in E. coli PA3092 and is due to a temperature-sensitive mutation. We tentatively named this mutation fic (filamentation induced by cAMP). The fic gene was located near rpsL (formerly strA) on the E. coli K-12 map. the inhibitory effect of cAMP on cell division and filamentation in a fic mutant was not observed in a crp mutant. When cAMP was removed from the culture medium, filaments were divided into rods as the intracellular cAMP level decreased. These results suggest that the cAMP-cAMP receptor protein complex causes filamentation in the fic mutant, E. coli PA3092. |
| Links | |
| Keywords |
Cell Division/drug effects; Chromosome Mapping; Chromosomes, Bacterial; Cyclic AMP/physiology; Escherichia coli/cytology; Escherichia coli/genetics; Escherichia coli/growth & development; Genes, Bacterial; Mutation; Receptors, Cyclic AMP/physiology; Temperature |
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