PMID:6215986
| Citation |
Grayhack, EJ and Roberts, JW (1982) The phage lambda Q gene product: activity of a transcription antiterminator in vitro. Cell 30:637-48 |
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| Abstract |
Phage lambda gene Q encodes a positive regulator of phage late gene expression. We show that purified Q gene protein functions as a transcription antiterminator in vitro. It acts at the terminator for lambda 6S RNA, a small constitutive transcript that precedes the late genes, thus opening transcription into the entire late gene region. It is active in a purified transcription system consisting otherwise of only RNA polymerase, L factor and DNA containing the region encoding the 6S RNA. Q protein thus acts directly on the transcription complex to alter its response to transcription terminators. |
| Links | |
| Keywords |
Bacteriophage lambda/genetics; Base Sequence; Gene Expression Regulation; Genes, Viral; RNA, Viral/biosynthesis; RNA, Viral/genetics; Transcription Factors/physiology; Transcription, Genetic; Viral Proteins/physiology |
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