PMID:6115852
| Citation |
Macchia, V, Caputo, G, Mandato, E, Rocino, A, Adhya, S and Pastan, I (1981) Guanylate cyclase activity in Escherichia coli mutants defective in adenylate cyclase. J. Bacteriol. 147:931-4 |
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| Abstract |
Guanylate cyclase, which catalyzes the synthesis of guanosine 3',5'-monophosphate, has been assayed in several strains of Escherichia coli. They include wild-type cells and mutants defective in adenylate cyclase, which is responsible for the synthesis of adenosine 3',5'-phosphate. Our results demonstrate that adenylate cyclase and guanylate cyclase are two different enzymes in E. coli and suggest that the gene that encodes adenylate cyclase also plays a regulatory role in the synthesis of guanylate cyclase. |
| Links | |
| Keywords |
Adenylate Cyclase/metabolism; Cyclic AMP/pharmacology; Cyclic GMP/biosynthesis; Escherichia coli/enzymology; Escherichia coli/genetics; Guanosine Triphosphate/metabolism; Guanylate Cyclase/metabolism; Manganese/pharmacology; Mutation; Sodium Fluoride/pharmacology |
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