PMID:4939769
| Citation |
Dempsey, WB and Arcement, LJ (1971) Identification of the forms of vitamin B 6 present in the culture media of "vitamin B 6 control" mutants. J. Bacteriol. 107:580-2 |
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| Abstract |
An Escherichia coli mutant resistant to isoniazid (WG497) contained 0.6 mumole of extracellular pyridoxamine and pyridoxamine phosphate in the early stationary phase. A suppressed lysine mutant (AT1024) contained 1.4 mumoles of pyridoxal phosphate under the same conditions. The internal concentration of vitamin B(6) was one-half of normal for AT1024 and increased fivefold for WG497. |
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| Keywords |
Biological Assay; Cell Membrane Permeability; Cell-Free System; Culture Media/analysis; Drug Resistance, Microbial; Escherichia coli/analysis; Escherichia coli/drug effects; Escherichia coli/growth & development; Escherichia coli/metabolism; Genetics, Microbial; Isoniazid/pharmacology; Mutation; Picolines/metabolism; Pyridoxal Phosphate/analysis; Pyridoxine/analysis; Pyridoxine/biosynthesis; Toluene; Yeasts |
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| Allele | Nt change(s) | AA change(s) | Phenotype: Type | Phenotype: Description | Reference | Availability | Comments | |
|---|---|---|---|---|---|---|---|---|
|
pdx |
Resistant to |
Resistant to Isoniazid |
Strain: WG497 |
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