PMID:4939758
| Citation |
Ron, EZ and Davis, BD (1971) Growth rate of Escherichia coli at elevated temperatures: limitation by methionine. J. Bacteriol. 107:391-6 |
|---|---|
| Abstract |
When Escherichia coli growing in minimal medium is shifted from 37 C to any temperature in the range 40 to 45 C, the growth rate immediately assumes a new, lower value, characteristic of that temperature. The decrease is shown to be due, in several strains, to decreased activity of the first enzyme of the methionine pathway, homoserine trans-succinylase, which thus appears to be more heat-sensitive than any other essential enzyme in the cell. This sensitivity does not involve progressive denaturation of the enzyme; rather, the response to a shift of temperature, in either direction, is immediate and reversible. |
| Links | |
| Keywords |
Acyltransferases/metabolism; Bacterial Proteins/biosynthesis; Carbon Isotopes; Cell Survival; Culture Media; Cystathionine/biosynthesis; DNA, Bacterial/biosynthesis; Escherichia coli/enzymology; Escherichia coli/growth & development; Escherichia coli/metabolism; Genetics, Microbial; Homoserine/metabolism; Hot Temperature; L-Serine Dehydratase/metabolism; Leucine/metabolism; Methionine/biosynthesis; Methionine/metabolism; Mutation; RNA, Bacterial/biosynthesis; Succinates; Uracil/metabolism |
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