PMID:4598299
| Citation |
Shine, J and Dalgarno, L (1974) The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites. Proc. Natl. Acad. Sci. U.S.A. 71:1342-6 |
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| Abstract |
With a stepwise degradation and terminal labeling procedure the 3'-terminal sequence of E. coli 16S ribosomal RNA is shown to be Pyd-A-C-C-U-C-C-U-U-A(OH). It is suggested that this region of the RNA is able to interact with mRNA and that the 3'-terminal U-U-A(OH) is involved in the termination of protein synthesis through base-pairing with terminator codons. The sequence A-C-C-U-C-C could recognize a conserved sequence found in the ribosome binding sites of various coliphage mRNAs; it may thus be involved in the formation of the mRNA.30S subunit complex. |
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| Keywords |
Bacterial Proteins/biosynthesis; Base Sequence; Binding Sites; Chromatography, Ion Exchange; Coliphages/metabolism; Electrophoresis, Paper; Escherichia coli/analysis; Genetic Code; Hydrolysis; Mutation; Oligonucleotides/analysis; Peptide Chain Initiation, Translational; Peptide Chain Termination, Translational; RNA, Bacterial/analysis; RNA, Bacterial/metabolism; RNA, Messenger/metabolism; RNA, Ribosomal/analysis; RNA, Ribosomal/metabolism; Ribonucleases; Ribosomes/metabolism; Tritium; Viral Proteins/biosynthesis |
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