PMID:4127628
| Citation |
Beckman, D and Cooper, S (1973) Temperature-sensitive nonsense mutations in essential genes of Escherichia coli. J. Bacteriol. 116:1336-42 |
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| Abstract |
Cells containing nonsense mutations in essential genes have been isolated in a strain of Escherichia coli that carried the su4(ts) gene which specifies a temperature-sensitive tyrosine transfer ribonucleic acid. Such cells are unable to form colonies at temperatures which inactivate this suppressor transfer ribonucleic acid. A screening procedure for the identification of mutants that carry temperature-sensitive nonsense mutations in essential genes is described, and certain properties of two such mutants are reported. |
| Links | |
| Keywords |
Chromosome Mapping; Escherichia coli/enzymology; Escherichia coli/isolation & purification; Escherichia coli/metabolism; Mutation; Nitrosoguanidines; Peptide Biosynthesis; Phenotype; RNA, Bacterial/biosynthesis; RNA, Transfer/biosynthesis; Staining and Labeling; Suppression, Genetic; Temperature; Transduction, Genetic |
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