PMID:4126826
| Citation |
De Felice, M, Guardiola, J, Lamberti, A and Iaccarino, M (1973) Escherichia coli K-12 mutants altered in the transport systems for oligo- and dipeptides. J. Bacteriol. 116:751-6 |
|---|---|
| Abstract |
Two mutants of Escherichia coli K-12, defective in the oligopeptide and dipeptide transport system, are described. A mutant defective in the oligopeptide transport system (opp-1) was isolated as resistant to the inhibitory action of triornithine; this mutant is also resistant to glycylglycylvaline and does not concentrate (14)C-glycylglycylglycine, although it is still as sensitive as the parental strain to glycylvaline and valine. Starting from the opp-1 strain, a mutant defective also in the dipeptide transport system (dpp-1) was isolated; this mutant is resistant to the inhibitory action of glycylvaline, valylleucine, and leucylvaline and does not concentrate (14)C-glycylglycine, although it is still as sensitive as the parental strain to valine. The apparent kinetic constants for oligopeptide and dipeptide transport were measured. The opp marker is co-transducible with trp at 27 min on the E. coli genetic map. The dpp locus is separated from opp and is located between proC (10 min) and opp. |
| Links | |
| Keywords |
Carbon Radioisotopes; Chromosome Mapping; Culture Media; Drug Resistance, Microbial; Escherichia coli/drug effects; Escherichia coli/metabolism; Glycine/metabolism; Mutation; Oligopeptides/metabolism; Peptides/metabolism; Staining and Labeling; Time Factors; Valine/metabolism |
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