PMID:4056740
| Citation |
Sugiyama, M, Paik, SY and Nomi, R (1985) Mechanism of self-protection in a puromycin-producing micro-organism. J. Gen. Microbiol. 131:1999-2005 |
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| Abstract |
Puromycin is a potent inhibitor of bacterial protein synthesis, but puromycin-producing Streptomyces alboniger KCC S-0309 is tolerant to the antibiotic in vivo. Puromycin bound to both 30S and 50S ribosomal subunits from S. alboniger and inhibited polyuridylate-directed polyphenylalanine synthesis by the ribosomes. However, the organism possessed a novel puromycin-inactivating enzyme which acetylated the antibiotic at the 2-NH2 group of the O-methyltyrosine moiety. |
| Links | |
| Keywords |
Acetylation; Acetyltransferases/metabolism; Drug Resistance, Microbial; Magnetic Resonance Spectroscopy; Puromycin/biosynthesis; Puromycin/pharmacology; Ribosomes/drug effects; Streptomyces/drug effects; Streptomyces/enzymology; Streptomyces/metabolism; Substrate Specificity |
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