PMID:3906038
| Citation |
Hrebenda, J, Heleszko, H, Brzostek, K and Bielecki, J (1985) Mutation affecting resistance of Escherichia coli K12 to nalidixic acid. J. Gen. Microbiol. 131:2285-92 |
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| Abstract |
A new mutation, nalD, determining resistance of Escherichia coli to nalidixic acid (NAL) is reported. The nalD mutant described is resistant to NAL at 37 degrees C but sensitive at 30 degrees C. It is defective in penetration of NAL and glycerol through the outer membrane at 37 degrees C. The nalD mutation is located half-way between 89 and 89.5 min on the E. coli genetic map. |
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| Keywords |
Biological Transport; Cell Membrane Permeability/drug effects; Chromosome Mapping; Conjugation, Genetic; DNA, Bacterial/biosynthesis; Drug Resistance, Microbial; Escherichia coli/drug effects; Escherichia coli/genetics; Escherichia coli/growth & development; Mutation; Nalidixic Acid/metabolism; Nalidixic Acid/pharmacology |
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