PMID:3902576

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Citation

Becerril, B, Valle, F, Merino, E, Riba, L and Bolivar, F (1985) Repetitive extragenic palindromic (REP) sequences in the Escherichia coli gdhA gene. Gene 37:53-62

Abstract

Deletions of the 3' flanking DNA region of the glutamate dehydrogenase (GDH) structural gene from Escherichia coli K-12, have been produced on a plasmid that carries the complete gdhA gene. Those deletions include part of the repetitive extragenic palindromic (REP) sequences proposed by Stern et al. [Cell 37 (1984) 1015-1026], as a novel and major feature of the bacterial genome. The effect of these deletions on the final GDH level in the cell, has been determined. A broader compilation, analysis and alternative functions of the REP sequences, is also presented.

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Keywords

Chromosome Deletion; Escherichia coli/genetics; Genes; Genes, Bacterial; Glutamate Dehydrogenase/genetics; Information Systems; Nucleic Acid Conformation; RNA, Messenger/genetics; Repetitive Sequences, Nucleic Acid; Sequence Homology, Nucleic Acid

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