PMID:3884381
| Citation |
Enberg, G and Holmgren, A (1985) Degradation of somatomedins by the thioredoxin system. FEBS Lett. 183:52-4 |
|---|---|
| Abstract |
The insulin disulfide reducing thioredoxin system from E. coli was used to investigate a possible mechanism of degradation for the two somatomedins, insulin-like growth factor I and II (IGF-I and -II). The amounts of IGF-I and -II remaining after degradation were measured by use of human placenta radioreceptor assay. The results show that both IGF-I and -II were as sensitive to disulfide reduction as insulin. |
| Links | |
| Keywords |
Bacterial Proteins/metabolism; Disulfides/metabolism; Escherichia coli/analysis; Female; Humans; Insulin/metabolism; Peptides/metabolism; Placenta/metabolism; Pregnancy; Radioligand Assay; Somatomedins/metabolism; Thioredoxin-Disulfide Reductase/metabolism; Thioredoxins/metabolism |
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