PMID:3884374

Citation	Stein, JM, Kornberg, HL and Martin, BR (1985) Effects of GTP,GDP[beta S] and glucose on adenylate cyclase activity of E. coli B. FEBS Lett. 182:429-34
Abstract	Adenylate cyclase activity was measured in suspensions of E.coli B, rendered permeable with toluene. The enzyme was activated in a dose-dependent manner by GTP and by its non-hydrolysable analogue, GTP[gamma S]. In contrast, incubation with GDP[beta S], a non-phosphorylatable analogue of GDP, caused a dose-related inhibition of adenylate cyclase; this was partially overcome by addition of GTP. GTP did not relieve, and GDP[beta S] augmented, the non-competitive and dose-related inhibition of E.coli adenylate cyclase by glucose.
Links	PubMed
Keywords	Adenylate Cyclase/antagonists & inhibitors; Adenylate Cyclase/metabolism; Enzyme Activation/drug effects; Escherichia coli/enzymology; Glucose/pharmacology; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate/analogs & derivatives; Guanosine Diphosphate/pharmacology; Guanosine Triphosphate/analogs & derivatives; Guanosine Triphosphate/pharmacology; Thionucleotides/pharmacology; Toluene/pharmacology
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