PMID:3542979
| Citation |
Wanner, BL (1987) Control of phoR-dependent bacterial alkaline phosphatase clonal variation by the phoM region. J. Bacteriol. 169:900-3 |
|---|---|
| Abstract |
phoR mutants with the wild-type Escherichia coli K-12 Var+ phoM region showed clonal variation of bacterial alkaline phosphatase synthesis, whereas mutants with the pho-510 Var- allele did not. The pho-510 mutation is responsible for the phoR mutant constitutive phenotype and probably arose in E. coli K-12 58F+ after X-ray mutagenesis over 40 years ago. I propose that the phoM region controls a change in state of bacterial alkaline phosphatase synthesis, at least in phoR mutants. Four possible molecular mechanisms for how phoM may act are discussed. |
| Links | |
| Keywords |
Alkaline Phosphatase/biosynthesis; Alkaline Phosphatase/genetics; Alleles; Escherichia coli/enzymology; Escherichia coli/genetics; Genes; Genes, Bacterial; Genetic Variation; Mutation |
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