PMID:331084
| Citation |
Yagil, E and Be'eri, H (1977) Arsenate-resistant alkaline phosphatase-constitutive mutants of Escherichia coli. Mol. Gen. Genet. 154:185-9 |
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| Abstract |
When arsenate-resistant mutants are selected approximately 50 per cent of them are also consitutive for the synthesis of alkaline phosphatase and the Pi-binding protein. Some of these mutants are linked to ilv (phoS- or phoT-), other are linked to proC (phoR-). One of the mutant strains linked to ilv lost the Pi-binding protein (the phoS gene product). Resistance to arsenate, constitutivty for alkaline phosphatase synthesis and loss of the Pi-binding protein occurred pleiotropically by the same phoS- mutation. |
| Links | |
| Keywords |
Alkaline Phosphatase/biosynthesis; Arsenates/pharmacology; Arsenic/pharmacology; Bacterial Proteins/analysis; Carrier Proteins/analysis; Chromosome Mapping; Drug Resistance, Microbial; Escherichia coli/drug effects; Escherichia coli/metabolism; Genetic Linkage; Immunoelectrophoresis; Mutation; Phosphates/metabolism; Protein Binding |
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