PMID:3086314
| Citation |
Buckel, SD, Bell, AW, Rao, JK and Hermodson, MA (1986) An analysis of the structure of the product of the rbsA gene of Escherichia coli K12. J. Biol. Chem. 261:7659-62 |
|---|---|
| Abstract |
The predicted amino acid sequence of rbsA, a gene from the high affinity ribose transport operon (rbs) of Escherichia coli K12, is homologous to the products of hisP, malK, and pstB, components of the histidine, maltose, and phosphate high affinity transport operons. The recent finding by Hobson et al. (Hobson, A. C., Weatherwax, R., and Ames, G.F.-L. (1984) Proc. Natl. Acad. Sci. U.S.A. 81, 7333-7337) that the hisP and malK products bind ATP suggests that these four gene products may be involved in coupling the energy from ATP to drive the active transport in their respective transport systems. Each gene product contains a sequence of glycine and basic residues which are characteristic of an ATP-binding site (Walker, J.E., Saraste, M., Runswick, M.J., and Gay, N.J. (1982) EMBO J. 1, 945-951). Interestingly the N- and C-terminal halves of rbsA are also homologous, suggesting that a primordial gene duplication and subsequent fusion of the products occurred. |
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| Keywords |
Amino Acid Sequence; Carrier Proteins/genetics; Carrier Proteins/isolation & purification; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins; Genes; Genes, Bacterial; Periplasmic Binding Proteins; Protein Biosynthesis; Ribose/metabolism; Sequence Homology, Nucleic Acid |
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