PMID:3049163
| Citation |
Schulz, A, Spönemann, P, Köcher, H and Wengenmayer, F (1988) The herbicidally active experimental compound Hoe 704 is a potent inhibitor of the enzyme acetolactate reductoisomerase. FEBS Lett. 238:375-8 |
|---|---|
| Abstract |
Growth inhibition of plants and bacteria by the experimental herbicide Hoe 704 (2-methylphosphinoyl-2-hydroxyacetic acid) was alleviated by the addition of the branched-chain amino acids to growth media. Hoe 704 caused a massive accumulation of acetoin and acetolactate, indicating its direct interference with the branched-chain amino acid biosynthetic pathway. The second enzyme of this pathway, acetolactate reductoisomerase (EC 1.1.1.86), was found to be subject to strong inhibition by Hoe 704. The inhibition was time-dependent and competitive with the enzyme's substrate, acetolactate. This report establishes acetolactate reductoisomerase as a new target for a herbicidal compound. |
| Links | |
| Keywords |
2-Acetolactate Mutase/antagonists & inhibitors; Amino Acids, Branched-Chain/biosynthesis; Escherichia coli/enzymology; Herbicides; Hydroxybutyrates/metabolism; Isomerases/antagonists & inhibitors; Kinetics; Klebsiella pneumoniae/drug effects; Lactates/metabolism; Organophosphorus Compounds/pharmacology; Plants/enzymology |
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