PMID:2914852
| Citation |
Leblond, P, Demuyter, P, Moutier, L, Laakel, M, Decaris, B and Simonet, JM (1989) Hypervariability, a new phenomenon of genetic instability, related to DNA amplification in Streptomyces ambofaciens. J. Bacteriol. 171:419-23 |
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| Abstract |
The wild-type strain Streptomyces ambofaciens DSM 40697 exhibits a high degree of genetic instability. Pigment-defective colonies were observed in the progeny of wild-type colonies at a frequency of about 0.01. While only 13% of these pigment-defective colonies gave rise to homogeneous progeny exhibiting the mutant parental phenotype, 87% of the mutant colonies gave rise to hetergeneous progeny without a preponderant phenotype. This new phenomenon of instability was called hypervariability. In addition, 21% of the mutant strains arising in hypervariable progeny contained highly reiterated DNA sequences, while amplified DNA sequences could be detected in neither stable pigment-defective mutant clones nor in wild-type clones. These results indicate a frequent association between genetic instability and hypervariability and a frequent association between hypervariability and amplification of DNA sequences. |
| Links | |
| Keywords |
DNA, Bacterial/genetics; Gene Amplification; Genes, Bacterial; Genetic Variation; Mutation; Restriction Mapping; Species Specificity; Streptomyces/genetics |
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